Light-Sheet Microscopes
For fast, 3D imaging of live or cleared-tissue samples
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See Biology Across All Scales
With a strong focus on applications, our light-sheet solutions are easy to use and enable scientists around the globe to excel in their research. The SPIM technology avoids sample phototoxicity by sequentially illuminating a stack of thin slices of the organism, allowing scientists to observe living organisms for extended periods of time without photodamage.
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Browse Our Light-Sheet Microscopy Library
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Browse Light-Sheet Microscopy Articles
| Year | Title | Author(s) | Imaging Platform | Subject | Methodology |
|---|---|---|---|---|---|
| 2022 | An ex vivo system to study cellular dynamics underlying mouse peri-implantation development (Developmental Cell) | Takafumi Ichikawa, Hui Ting Zhang, (…), Takashi Hiiragi | InVi, PM Module | Pre-implantaion development, Morphogenesis, Patterning | Mouse, Ex-vivo, Live imaging, Laser ablation |
| 2022 | Parallel evolution of a splicing program controlling neuronal excitability in flies and mammals (Science Advances) | Antonio Torres-Méndez, Sinziana Pop, (…), Manuel Irimia | MuVi LS | Neurobiology, Motor neuron activity | Drosophila, Calcium imaging |
| 2021 | Imaging translation dynamics in live embryos reveals spatial heterogeneities (Science) | Jeremy Dufourt, Maelle Bellec, (…), Mounia Lagha | MuVi LS | Embryogenesis, | Drosophila, SunTag, Live imaging, In-toto |
| 2021 | Dual spindles assemble in bovine zygotes despite the presence of paternal centrosomes (Journal of Cell Biology) | Isabell Schneider, Marta de Ruijter-Villani, (…), Jan Ellenberg | Prototype InVi | Embryogenesisi, Parental chromosomes, Spindle formation | Bovine, Live imaging |
| 2021 | Integration of cell growth and asymmetric division during lateral root initiation in arabidopsis thaliana (Plant and Cell Physiology) | Lilli Marie Schütz, Marion Louveaux, (…), Alexis Maizel | MuVi LS | Lateral root formation, Anticlinal and periclinal division | Arabidopsis, Live imaging |
| 2021 | Fish primary embryonic pluripotent cells assemble into retinal tissue mirroring in vivo early eye development (eLife) | Lucie Zilova, Venera Weinhardt, (…), Joachim Wittbrodt | MuVi LS | 眼发展,视网膜瀑样 | Medaka, Zebrafish, Organoides, Live imaging |
| 2021 | Mechanical competition alters the cellular interpretation of an endogenous genetic program (Journal of Cell Biology) | Sourabh Bhide, Denisa Gombalova, (…), Maria Leptin | Prototype MuVi LS | Embryogenesis, Gastrulation | Drosophila, Live imaging, In-toto |
| 2021 | Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways (Nature Communications) | Luca Guglielmi, Claire Heliot, (…), Caroline S. Hill | MuVi LS | Embryogenesis, Gen regulation, mRNA | Zebrafish, Live imaging, In-tot |
| 2021 | Endothelial Wnts control mammary epithelial patterning via fibroblast signaling (Cell Reports) | Jingqiang Wang, Wenqian Song, (…), Yi Arial Zeng | MuVi CS | Mammary Gland, whole-tissue imaging | Mouse, Tissue Clearing |
| 2020 | Cell death in cells overlying lateral root primordia facilitates organ growth in arabidopsis (Current Biology) | Sacha Escamez, Domenique André, (…), Hannele Tuominen | MuVi LS | Lateral roots, Organ growth | Arabidopsis, Live imaging |
| 2020 | Axis specification in zebrafish is robust to cell mixing and reveals a regulation of pattern formation by morphogenesis (Current Biology) | Timothy Fulton, Vikas Trivedi, (…), Benjamin Steventon | MuVi LS | Embryogenesis, Early pescoids, Cell division patterns, Cell rearrangement | Zebrafish, Live imaging, In-tot |
| 2020 | Contact area–dependent cell communication and the morphological invariance of ascidian embryogenesis (Science) | Léo Guignard, Ulla-Maj Fiúza, (…), Patrick Lemaire | MuVi LS | Embryogenesis, Cell lineages, Morphology | Ascidience, Live imaging, In-toto |
| 2020 | MorphoSeq: Full single-cell transcriptome dynamics up to gastrulation in a chordate (Cell) | Hanna L. Sladitschek, Ulla-Maj Fiuza, (…), Pierre A. Neveu | Prototype MuVi LS | Embryogenesis, Genome-wide gen expression | Ascidian 'Phallusia mammillata', in-toto, live imaging, scRNA-seq |
| 2020 | Cell and tissue manipulation with ultrashort infrared laser pulses in light-sheet microscopy (Scientific Reports) | Gustavo de Medeiros, Dimitri Kromm, (…), Lars Hufnagel | Prototype MuVi , PM Module | MuVi, Cell and tissue manipulation, Ablation | Drosophila, Live imaging, Multiphoton ablation |
| 2020 | Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation (eLife) | Ashna Alladin, Lucas Chaible, (…), Martin Jechlinger | InVi | Tumor organiodes, Mammary epithelial acini, oncogenes | Mouse, Organoids, Live imaging |
| 2019 | A tug-of-war between cell shape and polarity controls division orientation to ensure robust patterning in the mouse blastocyst (Developmental Cell) | Ritsuya Niwayama, Prachiti Moghe, (…), Takashi Hiiragi | InVi | Embryogenesis, Cell Shape, Division pattern | Mouse, Live imaging, In-tot, Lineage tracing |
| 2018 | Bicoid gradient formation mechanism and dynamics revealed by protein lifetime analysis (Molecular Systems Biology) | Lucia Durrieu, Daniel Kirrmaier, (…), Michael Knop | Prototype MuVi LS | Embryogenesis, Morphogen distripution | Drosophila, In-toto, live imaging |
| 2018 | Dual-spindle formation in zygotes keeps parental genomes apart in early mammalian embryos (Science) | Judith Reichmann, Bianca Nijmeijer, (…), Jan Ellenberg | Prototype InVi | Embryogenesisi, Parental chromosomes, Spindle formation | Mouse, Live imaging |
| 2015 | Inverted light-sheet microscope for imaging mouse pre-implantation development (Nature Methods) | Petr Strnad, Stefan Gunther, (…), Jan Ellenberg | Prototype InVi | Embryogenesisi, Zygote, Blastocyst | Mouse, Live imaging, In-tot, Lineage tracing |
| 2015 | Confocal multiview light-sheet microscopy (Nature Communications) | Gustavo de Medeiros, Nils Norlin, (…), Lars Hufnagel | Prototype MuVi LS | Confocal MuVi, Full Frame MuVi, Data Fusion | Drosophila, Live imaging, Line detetcion |
| 2012 | Multiview light-sheet microscope for rapid in toto imaging (Nature Methods) | Uros Krzic, Stefan Gunther, (…), Lars Hufnagel | Prototype MuVi | Muvi, Embryogenesis, Cell Tracking | Drosophila, live imaging, in-toto |