Pharmaceutical and biopharmaceutical drug discovery

ADME - toxicology,

Due to some unpredictable toxicological properties of drug candidates through the last stage of experiment, and the high cost of drug development also will be terminated.It is imperative that as far as possible in the earliest stages of drug discovery process, reducing attrition rate.

Such as magnetic resonance imaging (MRI), PET, SPETCT and micro CT imaging technology, through the longitudinal control the test compounds, and to provide information on security responsibility.The preclinical animal can be used as its own control, and by using a non invasive technique, such as PET and SPECT - such technology can be used to determine the position in the target/miss effect, to study the drug distribution.Combined with MRI, micro CT and PET provided anatomical and functional parameters, can the accurate determination of efficacy off-target effects related side effects.In fact, no matter in lead optimization phase or in the use of animals in the process of safety assessment, these technologies can with the fastest speed in the same experimental animals on the determination of distribution, efficacy and toxicity.This and rely on the in vitro tissue, compared to traditional time point analysis method is totally different.

In vivo imaging technology is more and more widely used to determine the main cause of drug consumption, such as liver, kidney, heart and brain toxicity, response to the new drugs and other organs and tissues.

Fully standardized and fully automatic nuclear magnetic resonance (NMR) metabolic analysis platform is the ideal of high-performance human body fluid analysis and unique technology selection, effectively in clinical metabonomics research and related testing development (research only use level).

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