Quantitative nuclear magnetic resonance (qNMR)

Titer evaluation, absolute purity determination, compound identification test, solvent residue, moisture content analysis, the relative response factor calculation......You ever thought about using quantitative nuclear magnetic resonance (qNMR) as a one-stop solution?

In the past, used to develop test of conventional detection methods usually contains a number of experiments and technology [1].Using quantitative nuclear magnetic resonance (NMR) titer determination of this comprehensive method, has been successfully replaced the conventional method, and the determination of the purity of reference standard sample, [2] has unique superiority.The standard sample is usually used to analyze the reliable quantity traceability (such as HPLC standard sample).

At present, the lack of quantitative nuclear magnetic resonance (NMR) technology in their work processes rely on the professional knowledge, skilled analysts and detailed operation process.Brooke Mestrelab for titer/launched by the determination of purity of new tools to simplify the workflow, achieved from the experiment final report submitted to the workflow automation.Because of drug quality in drug development is crucial, so for those who work in the drug development environment and the experts, the solution is the ideal choice.

• Online management of samples and analysis process
• Including potency determination of automatic data analysis, by integrating automatic numerical selection or predefined spectra regions
• Within the sample error analysis: when multiple analytes are integrated spectral peak, average RSD is given
• Extensive integration methods, including Global Spectra Deconvolution (GSD) and quantitative GSD (qGSD)
• Deliver results in electronic form and PDF form, can be selected to customize a template
• Based on the optimization of the rapid development of the default configuration and qNMR method, can be used for acquisition, processing and analysis

After a brook and Mestrelab continued validation for nuclear magnetic resonance (NMR) quantitative algorithm, automatic data analysis function arises at the historic moment.This feature can be invoked automatically from Mdrive, can also be performed manually.In addition to the automatic analysis, all of the data processing and subsequent analysis functions can be manually by simple way.

Mdrive qNMR GxP

Based on the new platform for the GxP, brooke's qNMR products are now available from the initial problem to full traceability of test results, and can be for users and their rights and interests of all aspects of management.Experiments of online submission to ensure the log in and log out.The structure is based on database constructed, to ensure the data integrity and manageability of qNMR method.These methods are usually designed by the method development personnel, and upon the approval of the method validation personnel, and give them to scientists in the laboratory use.Quantitative nuclear magnetic resonance (NMR) can do it, now, in the GxP environment by optimizing the instrument use time, efficiently manage all kinds of analytical requirements.

1. Webster G.F. and Kumar, S., Anal Chem, 86, 11474 (2014).

2. Pauli G.F. Godecke t., Jaki B.U. and Lankin d.c., j. Nat Prod, 75, 834 (2012).

3. The Japanese Pharmacopeia XVII, General Tests and Apparatus, p. 137

• Multi-function: without chemical level equivalent to the reference material, use commercial reference standard
• More fast: nuclear magnetic resonance (NMR) technology is essentially a quantitative, don't need to calculate the response coefficient or calibration curve
• All-in-one: in a single experiment can titer and the structure are measured, organic and inorganic materials have been taken into consideration, without using other technologies
• Accuracy: the use of internal standard can eliminate inherent differences lead to the error of the sample
• Repeatability: from the analysis of the collected workflow automation can reduce human error and variation
• Intuitive and flexible: according to the need can be directly for manual operation